I've always had great respect and admiration for Helen Keller, who became deaf and blind at the age of 19 months yet learned to read, write and speak, inspiring people all over the world before dying in 1968 at the age of 87. Amazing, to me she fits the definition of a great American.
The 1962 movie The Miracle Worker is about how Anne Sullivan, who came from a horrible background, living and moving through various insane asylums in the rundown areas of NYC in the late 19th century, struggled with Helen, who was from a well-to-do Alabama family and was basically like a wild untrained animal, and eventually got through to her. Even for a movie that old it has some intense scenes. Anne Bancroft won the Academy Award for Best Actress for her portrayal of Sullivan, and Patty Duke won Best Supporting Actress for her portrayal of Helen Keller.
I always thought Anne Bancroft was Jewish. Being married to Mel Brooks certainly didn't hurt that impression. But she was Italian, born Anna Maria Louisa Italiano. She is probably best known as Mrs. Robinson in The Graduate, the groundbreaking 1967 movie that helped usher in the counterculture in Hollywood productions and the U.S. itself.
Patty Duke was tremendous as the young Helen Keller. She was 16 in 1962 but looked much younger in the movie. She was an American icon for a while, later in the 1960s having a popular TV sitcom called The Patty Duke Show in which she played identical cousins (!). She starred in the 1967 camp film Valley of the Dolls, but her adult life went downhill and she passed in 2016 at the relatively young age of 69.