I'm not sure it's the type of offense. It's the qb leading the offense. If teams were to shut Henry down by loading the box you would have to be able to hit outside receivers to make the defense pay. If they're blitzing you have to get the ball out quick, and know when to run and know when and where to throw because there will be a hole in coverage if there is a blitz.
It's no different with the Ravens offense, the Titans loaded up to stop the inside run, stringing everything to the sidelines . They were able to get small chunks but no huge plays. Forcing Lamar to throw to the outside receivers, and he struggled to make those throws and the receivers struggled to catch . He had time to throw.
Tannehill probably would have fared better had be been running the same offense , there's just the matter of the receivers dropping passes. I'm positive he would have audibled out of the 4th and short because of the defense he saw, or he would have taken a timeout. Well, he probably would have hit the receiver who was past the first down marker instead of the closer one who was short of the first down marker. He probably is also less likely to overthrow on the one play that turned into an interception. Lamar looked like garbage but if only a few plays had changed it probably would have been a different outcome because they don't go down 14 to 0 .
I do think that if they were somehow to contain Henry then the Titans might struggle without Adam Humphries, he's a threat on short passes. If they get down early they could become one dimensional allowing the defense to put more pressure on Tannehill to get the ball out quick. Henry is not known as a receiving back so you would have to get the ball to the tight ends and slot receivers . The bigger concern are the 49ers. Their last game nothing was working against them, they stopped the run game, they were in Cousin's face every pass play and none of the receivers were getting consistent separation. Maybe Henry could have more success running since he's bigger.
I have no doubt that Tannehill would be a winner running the Raven's offense but the main concern is exposing your franchise qb to so much wear and tear. So the fact that they are running Lamar so often leads me to believe he wouldn't have success running Tannehills offense.
It's the same thing that happened to RG3, I read that Shanahan wanted to continue to run him in the college offense, but the owner didn't because of injuries. Rg3 simply couldn't run the pro style offense